Food effect on the bioavailability of two distinct formulations of megestrol acetate oral suspension

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Food effect on the bioavailability of two distinct formulations of megestrol acetate oral suspension

OBJECTIVE Megestrol acetate oral suspension (MAOS) is an appetite stimulant indicated for cachexia in patients with AIDS. It is available in its original formulation, Megace (MAOS), and as a nanocrystal dispersion, Megace ES (MA-ES). Three studies were conducted to evaluate the pharmacokinetic properties of these formulations under fed and fasting conditions. METHODS An open-label, crossover ...

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ژورنال

عنوان ژورنال: International Journal of Nanomedicine

سال: 2009

ISSN: 1178-2013

DOI: 10.2147/ijn.s6308